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The 62 pages that link to Autosomal dominant inheritance, each with the reason it gives.
Genetic counselingRelated: Recognizing this pattern helps explain why a variant may affect multiple generations.
Familial hypercholesterolemiaRelated: Most familial hypercholesterolemia is inherited this way, with each affected parent having a 50% transmission chance.
Malignant hyperthermiaRelated: Susceptibility is commonly inherited this way, so it can pass through successive generations.
Retinitis pigmentosaRelated: Some forms pass through successive generations when a single variant is sufficient.
Huntington's diseaseRelated: One expanded HTT copy is sufficient to cause Huntington's disease.
Hypertrophic cardiomyopathyRelated: Many disease-causing variants are passed through families in this pattern.
De novo mutationRelated: A dominant disorder can appear in a child through a new variant despite no affected parent.
SyndactylyRelated: Several inherited forms of syndactyly follow this pattern.
HaploinsufficiencyRelated: Haploinsufficient variants often produce disease despite an intact allele.
Genetic disorderRelated: This inheritance pattern explains disorders that can affect successive generations.
22q11.2 deletion syndromeRelated: An affected parent can transmit the deletion, although most cases arise de novo.
Osteogenesis imperfectaRelated: Many cases are inherited this way, though new variants also occur.
PolydactylyRelated: Many isolated forms of polydactyly can be inherited this way.
DiGeorge syndromeRelated: When a parent carries the deletion, each pregnancy has a 50% chance of inheriting it.
Lynch syndromeRelated: A pathogenic variant in one mismatch-repair gene copy can confer Lynch-associated cancer risk.
Ehlers–Danlos syndromeRelated: Many molecularly defined Ehlers–Danlos types follow this inheritance pattern.
Hereditary spherocytosisRelated: Many cases are passed from an affected parent through dominant inheritance.
AchondroplasiaRelated: One FGFR3 variant is sufficient, though many affected children inherit a variant from neither parent.
PorphyriaRelated: Several acute porphyrias are inherited this way, though many carriers never develop attacks.
Liddle syndromeRelated: Liddle syndrome commonly appears across generations through this pattern.
Noonan syndromeRelated: Many cases follow this pattern, though a new variant is common and severity varies.
Spinocerebellar ataxiaRelated: Many spinocerebellar ataxias pass through families in this pattern.
Apert syndromeRelated: A single disease-causing FGFR2 variant can produce Apert syndrome.
Familial adenomatous polyposisRelated: A person with a germline APC variant has a one-in-two chance of passing it to each child.
Waardenburg syndromeRelated: Many Waardenburg syndrome cases follow this pattern, though inheritance varies by gene and subtype.
Alexander diseaseRelated: Most Alexander disease cases result from de novo GFAP variants, though inherited cases occur.
Charcot–Marie–Tooth diseaseRelated: Many CMT forms can pass from an affected parent to a child through this pattern.
Crouzon syndromeRelated: Crouzon syndrome is commonly inherited this way, though new variants also occur.
Myotonic dystrophyRelated: Each main form can be passed from an affected parent to a child.
Pfeiffer syndromeRelated: Pfeiffer syndrome can pass from an affected parent to a child through this pattern.
AniridiaRelated: Many familial cases of PAX6-related aniridia follow this inheritance pattern.
Hereditary spastic paraplegiaRelated: Many common forms follow this pattern, though inheritance varies among subtypes.
Hypokalemic periodic paralysisRelated: The classic inherited form often passes through families in this pattern.
Loeys–Dietz syndromeRelated: Many Loeys–Dietz syndrome cases follow this pattern, although new variants also occur.
Peutz–Jeghers syndromeRelated: A single inherited STK11 variant can predispose someone to the syndrome.
Von Hippel–Lindau diseaseRelated: VHL disease is usually inherited this way, though new variants also occur.
Amelogenesis imperfectaRelated: Some forms of amelogenesis imperfecta follow this inheritance pattern.
EctrodactylyRelated: Some inherited forms of split-hand/foot malformation follow this pattern, with variable expression.
Rubinstein–Taybi syndromeRelated: The syndrome follows this inheritance pattern, though most cases arise from new variants.
CherubismRelated: Cherubism is commonly inherited this way, though new mutations also occur.
Cleidocranial dysostosisRelated: A person with a RUNX2-related case may pass the variant to each child with a 50% chance.
Cornelia de Lange syndromeRelated: Most established Cornelia de Lange syndrome gene variants act dominantly, often arising de novo.
Darier diseaseRelated: Affected individuals commonly have a one-in-two chance of passing the variant to each child.
Fibrodysplasia ossificans progressivaRelated: The disorder follows this inheritance pattern, although most cases result from new mutations.
Stickler syndromeRelated: Most Stickler syndrome forms are inherited this way, though severity can vary within families.
Treacher Collins syndromeRelated: Many cases result from a dominant variant inherited from a parent or arising for the first time.