Linked from

The 56 pages that link to Cytochrome P450, each with the reason it gives.

• Drug interactionRelated: Inhibition or induction of these enzymes can raise or lower concentrations of affected drugs.

• PharmacogenomicsRelated: Variants in CYP genes can speed or slow the breakdown of particular medicines.

• Drug metabolismRelated: These enzymes carry out many drug-oxidation reactions and drive clinically significant interactions.

• AcetaminophenRelated: A small fraction of acetaminophen is oxidized by these enzymes into a reactive metabolite.

• HemeRelated: Its heme activates oxygen for chemical transformations of substrates.

• MacrolideRelated: Erythromycin and clarithromycin can inhibit CYP3A4 and alter concentrations of interacting medicines.

• ProdrugRelated: Some prodrugs rely on P450 oxidation to form their active metabolites.

• CYP3A4Narrower topic: CYP3A4 is one member of this enzyme family and uses its characteristic heme-based chemistry.

• First-pass effectRelated: Intestinal and hepatic P450 enzymes metabolize numerous drugs during absorption.

• SteroidRelated: Several members catalyze key modifications in steroid hormone pathways.

• Arachidonic acidRelated: P450 enzymes form additional signaling products from arachidonic acid.

• NADPHRelated: NADPH supplies electrons for many cytochrome P450 reactions.

• HepatocyteRelated: These enzymes let hepatocytes transform many compounds for elimination.

• SteroidogenesisNarrower topic: Several key steroidogenic enzymes belong to this enzyme family.

• PorphyrinRelated: Its heme porphyrin activates oxygen for chemical transformations.

• OndansetronRelated: Several CYP enzymes contribute to ondansetron metabolism and interactions.

• Natural productRelated: P450 enzymes often tailor natural-product structures after their initial assembly.

• Alcohol dehydrogenaseCompared with: CYP2E1 provides an alternative route for ethanol oxidation, especially at high ethanol concentrations.

• CYP2D6Narrower topic: CYP2D6 belongs to this enzyme family and shares its drug-oxidation chemistry.

• FluoxetineRelated: Fluoxetine inhibits CYP2D6, creating clinically relevant drug interactions.

• Herb–drug interactionRelated: Herbal compounds can inhibit or induce these enzymes, changing how quickly a medicine is cleared.

• SertralineRelated: These enzymes metabolize sertraline and contribute to drug interactions.

• Terpene synthaseCompared with: P450 enzymes often modify terpene skeletons after terpene synthases create them.

• Acetaminophen poisoningRelated: These enzymes generate the reactive metabolite responsible for much of the liver injury.

• ErythromycinRelated: Erythromycin inhibits CYP3A4, creating clinically significant interactions with some medicines.

• TerpenoidRelated: P450 enzymes often add oxygen or rearrange terpene-derived frameworks during biosynthesis.

• AromataseNarrower topic: Aromatase belongs to this enzyme family and uses its characteristic oxidative chemistry.

• CyclophosphamideRelated: Several cytochrome P450 enzymes initiate cyclophosphamide activation.

• PiperineRelated: Piperine can inhibit some of these enzymes, changing the breakdown of certain compounds.

• Active metaboliteRelated: These enzymes generate many active metabolites through oxidation.

• Azole antifungalNarrower topic: The azole target is a fungal P450 enzyme, which helps explain drug interactions and selectivity.

• FuranRelated: These enzymes metabolize furan into reactive products implicated in liver toxicity.

• Phenylpropanoid pathwayNarrower topic: P450 enzymes perform several hydroxylation steps within phenylpropanoid metabolism.

• CannabidiolRelated: CBD can inhibit some enzymes in this family, creating clinically relevant drug interactions.

• Nicotinamide adenine dinucleotide phosphateRelated: NADPH powers many P450 reactions involved in synthesis and chemical metabolism.

• PhenobarbitalRelated: Phenobarbital induces several of these enzymes, altering the levels of many co-administered medicines.

• AflatoxinRelated: Liver P450 enzymes convert aflatoxin B1 into a reactive metabolite that can bind DNA.

• Benzo(a)pyreneRelated: These enzymes begin converting benzo(a)pyrene into reactive metabolites.

• Carbon tetrachlorideRelated: Liver cytochrome P450 enzymes convert CCl₄ into reactive products that drive toxicity.

• CimetidineRelated: Cimetidine inhibits several of these enzymes, altering the breakdown of interacting medicines.

• CoumarinRelated: Liver P450 enzymes oxidize coumarin during its metabolism.

• MalathionRelated: Some cytochrome P450 enzymes convert malathion into the more potent malaoxon.

• PhenanthreneRelated: These enzymes can metabolize phenanthrene into more reactive products.

• PhenylpropanoidNarrower topic: Several pathway steps depend on P450 enzymes that modify aromatic rings and side chains.

• ClomipramineNarrower topic: These enzymes shape clomipramine’s metabolism and interactions with other medicines.

• Julius AxelrodRelated: Axelrod’s drug-metabolism research helped establish the significance of microsomal oxidation.

• NitrosamineRelated: P450 enzymes can metabolically activate certain nitrosamines into DNA-reactive intermediates.

• ClotrimazoleRelated: Clotrimazole inhibits a fungal P450 enzyme and can also affect human drug-metabolizing enzymes.

• FluconazoleNarrower topic: Fluconazole targets a fungal member of this enzyme family and can also affect human P450 enzymes.

• RitonavirNarrower topic: Ritonavir’s inhibition of CYP3A4 is one instance of drug effects on this enzyme family.