Linked from

The 49 pages that link to DNA repair, each with the reason it gives.

• DNARelated: Repair systems preserve information despite chemical damage and copying errors.

• MutationRelated: Repair systems prevent many DNA lesions and copying errors from becoming mutations.

• EpigeneticsCompared with: Repair changes or restores DNA itself, unlike epigenetic regulation of its activity.

• Genetic recombinationNarrower topic: Recombination is both a source of genetic variation and a way to repair DNA.

• CancerRelated: Defective repair allows mutations that contribute to cancer to accumulate.

• CarcinogenCompared with: Repair can prevent carcinogen-induced lesions from becoming lasting mutations.

• Nicotinamide adenine dinucleotideRelated: PARP-mediated repair responses consume NAD while signaling and organizing damage responses.

• CRISPR gene editingRelated: Repair pathways determine whether a CRISPR-induced break disrupts or alters a target gene.

• Somatic mutationRelated: Repair systems prevent many somatic mutations from becoming permanent.

• DNA damageCompared with: Repair counters damage, although imperfect repair can leave mutations or structural changes.

• DNA polymeraseNarrower topic: Repair polymerases fill DNA gaps after damaged or incorrect sections are removed.

• GenomeRelated: Repair preserves genome sequence against damage and copying errors.

• CarcinogenesisRelated: Repair defects allow DNA lesions to persist and contribute to mutations.

• CRISPR-Cas9Related: Repair of Cas9-induced breaks creates mutations or incorporates supplied DNA.

• PhotoprotectionRelated: Repair reverses lesions that photoprotection mechanisms did not prevent.

• Tumor suppressor geneRelated: Tumor suppressors can preserve genome integrity by supporting or regulating DNA repair.

• ChromatinRelated: Repair proteins must access damaged sites within packaged chromatin.

• TelomereCompared with: Telomeres protect natural chromosome ends from being mistaken for breaks requiring repair.

• DNA ligaseRelated: Several repair pathways leave DNA breaks that ligase must close.

• Phosphodiester bondRelated: Repair enzymes restore broken or damaged phosphodiester backbones to preserve chromosomes.

• Chromatin remodelingRelated: Remodelers reorganize chromatin so repair proteins can reach damaged DNA.

• MutagenesisRelated: Repair can prevent mutagenesis or, when error-prone, introduce mutations.

• ThermophileRelated: High temperatures can damage genetic material, making repair essential to thermophile survival.

• Molecular geneticsRelated: Repair systems preserve genetic information despite molecular damage.

• PyrimidineRelated: Repair systems remove pyrimidine lesions such as thymine dimers and uracil in DNA.

• Alkylating agentRelated: Repair pathways determine whether alkylated DNA is restored, tolerated, or lethal.

• Endosymbiotic gene transferRelated: Repair of nuclear breaks can incorporate DNA fragments released by organelles.

• Radiation-induced cancerRelated: Repair can restore irradiated DNA or leave errors that contribute to malignancy.

• Base editingRelated: Repair pathways help convert the editor's chemical change into a stable DNA substitution.

• NucleosomeRelated: Nucleosome disruption and reassembly help repair proteins reach damaged DNA.

• ThymineRelated: Repair systems recognize thymine-related lesions and mismatches.

• Emmanuelle CharpentierRelated: After Cas9 cuts a target, cells' repair pathways produce the edits used in genome engineering.

• Jennifer DoudnaRelated: Cells repair Cas9-induced breaks, producing the edits that genome engineering exploits.

• MutagenRelated: Repair systems counteract mutagens, while repair failures can magnify their effects.

• NitrosamineRelated: Repair pathways can remove lesions caused by reactive nitrosamine metabolites.

• RadiobiologyRelated: Repair determines whether radiation lesions are restored, misrepaired, or left unrepaired.

• Xeroderma pigmentosumNarrower topic: XP research became a landmark in connecting inherited disease with DNA-repair pathways.

• Bloom syndromeNarrower topic: Bloom syndrome arises from impairment of a DNA repair and replication-maintenance protein.

• Tomas LindahlNarrower topic: Lindahl’s discoveries helped establish DNA repair as a distinct field of study.

• TransformationRelated: Repair pathways can affect the fate of incoming DNA and its integration.

• Jack W. SzostakRelated: Telomeres prevent chromosome ends from being mistaken for DNA breaks requiring repair.

• SulfolobusRelated: Sulfolobus must repair DNA lesions caused by heat and environmental stress.

• ChlorambucilRelated: Repair capacity can influence how sensitive a cancer cell is to chlorambucil.

• Evolution of sexual reproductionRelated: Repairing DNA damage is a leading explanation for the early advantage of recombination.

• HelicaseRelated: Repair pathways use helicases to open DNA around lesions and processing sites.

• ThermoproteotaRelated: Thermoproteota face accelerated DNA damage at high temperatures and rely on repair systems.

• Werner ArberCompared with: Restriction cuts foreign DNA as defense, whereas repair restores or replaces damaged DNA.

• Werner syndromeRelated: Impaired repair contributes to genomic instability in Werner syndrome.

• Tsuneko OkazakiRelated: The enzymes that process replication fragments also connect replication to DNA maintenance.