Linked from

The 19 pages that link to Homologous recombination, each with the reason it gives.

• DNA replicationRelated: Cells can use it to restart damaged replication forks and repair broken DNA.

• DNA repairRelated: It restores broken DNA accurately when a matching template, usually a sister chromatid, is available.

• DNA damageRelated: It can restore broken DNA accurately using a sister chromatid as a template.

• Genetic engineeringRelated: Engineered DNA templates can guide targeted sequence replacement through this process.

• Genetic linkageRelated: Meiotic crossing over is the recombination process that separates linked loci.

• Genome editingRelated: Cells can use this repair pathway to incorporate an intended sequence after a targeted cut.

• BRCA1Related: BRCA1 helps direct double-strand breaks into this high-fidelity repair pathway.

• Pseudoautosomal regionRelated: Sequence similarity allows the X and Y chromosomes to exchange DNA in these regions.

• Site-directed mutagenesisRelated: It can install designed variants in chromosomes, extending targeted mutation beyond plasmid constructs.

• Martin EvansRelated: It enabled designed DNA changes to replace matching sequences in embryonic stem cells.

• Bloom syndromeRelated: BLM helps regulate this repair pathway and limits exchanges between matching chromosomes.

• Fanconi anemiaRelated: Fanconi anemia repair ultimately relies on this pathway to resolve crosslink-associated DNA breaks.

• Schizosaccharomyces pombeRelated: Fission yeast provides a genetically tractable system for studying this repair pathway.

• TransformationRelated: It can integrate imported DNA into the recipient chromosome.

• Evolution of sexual reproductionRelated: Its DNA-repair role offers a proposed evolutionary precursor to meiotic recombination.

• Mario CapecchiRelated: Capecchi showed that this process could insert designed DNA changes at matching sites in mammalian cells.