KnowraHuntington's diseaseLinked fromLinked fromThe 16 pages that link to Huntington's disease, each with the reason it gives.All 16Broader topic 8Related 4Compared with 4Autosomal dominant inheritanceBroader topic: It is a well-known adult-onset condition with autosomal dominant inheritance.Basal gangliaRelated: Early striatal degeneration alters action control and can produce involuntary movements.NeurodegenerationBroader topic: A defined genetic mutation causes progressive degeneration, especially in the striatum.Preimplantation genetic testingRelated: Testing may help people at risk avoid transmitting the disease-causing variant.PenetranceBroader topic: Long HTT CAG expansions provide a classic example of age-dependent penetrance.Variable expressivityBroader topic: Repeat length and other influences contribute to variation in onset and clinical course.Genotype–phenotype correlationBroader topic: Repeat length is associated with age of onset, illustrating a measurable genotype–phenotype relationship.Tardive dyskinesiaCompared with: Its choreiform movements can resemble tardive dyskinesia, but its cause and progression differ.Vesicular monoamine transporter 2Related: VMAT2 inhibitors can reduce chorea, a characteristic motor symptom.ChoreaBroader topic: Its chorea can affect function and identity alongside cognitive and psychiatric changes.Myotonic dystrophyCompared with: Both involve repeat expansion, but affect different genes and primarily different tissues.Point mutationCompared with: Its mutation is a repeat expansion, not a single-position point mutation.Dominant traitBroader topic: One disease-associated allele can be sufficient for the characteristic autosomal dominant inheritance pattern.Neurodegenerative diseaseBroader topic: Its known genetic cause contrasts with disorders that usually arise without a single inherited mutation.Lethal alleleCompared with: Its dominant allele is typically compatible with reproduction, unlike alleles lethal before reproduction.Victor A. McKusickRelated: Its dominant inheritance illustrates the disease patterns recorded in his catalog.
KnowraHuntington's diseaseLinked fromLinked fromThe 16 pages that link to Huntington's disease, each with the reason it gives.All 16Broader topic 8Related 4Compared with 4Autosomal dominant inheritanceBroader topic: It is a well-known adult-onset condition with autosomal dominant inheritance.Basal gangliaRelated: Early striatal degeneration alters action control and can produce involuntary movements.NeurodegenerationBroader topic: A defined genetic mutation causes progressive degeneration, especially in the striatum.Preimplantation genetic testingRelated: Testing may help people at risk avoid transmitting the disease-causing variant.PenetranceBroader topic: Long HTT CAG expansions provide a classic example of age-dependent penetrance.Variable expressivityBroader topic: Repeat length and other influences contribute to variation in onset and clinical course.Genotype–phenotype correlationBroader topic: Repeat length is associated with age of onset, illustrating a measurable genotype–phenotype relationship.Tardive dyskinesiaCompared with: Its choreiform movements can resemble tardive dyskinesia, but its cause and progression differ.Vesicular monoamine transporter 2Related: VMAT2 inhibitors can reduce chorea, a characteristic motor symptom.ChoreaBroader topic: Its chorea can affect function and identity alongside cognitive and psychiatric changes.Myotonic dystrophyCompared with: Both involve repeat expansion, but affect different genes and primarily different tissues.Point mutationCompared with: Its mutation is a repeat expansion, not a single-position point mutation.Dominant traitBroader topic: One disease-associated allele can be sufficient for the characteristic autosomal dominant inheritance pattern.Neurodegenerative diseaseBroader topic: Its known genetic cause contrasts with disorders that usually arise without a single inherited mutation.Lethal alleleCompared with: Its dominant allele is typically compatible with reproduction, unlike alleles lethal before reproduction.Victor A. McKusickRelated: Its dominant inheritance illustrates the disease patterns recorded in his catalog.