Linked from

The 31 pages that link to Lysosome, each with the reason it gives.

• PhagocytosisRelated: Lysosomes supply the enzymes and acidic conditions used to digest engulfed cargo.

• AutophagyRelated: Its enzymes digest cargo delivered by autophagosomes.

• MacrophageRelated: Fusion with phagosomes exposes engulfed material to destructive enzymes.

• EndocytosisRelated: Endocytosed cargo destined for destruction is delivered to lysosomes.

• OrganelleBroader topic: Lysosomes break down cargo and recycle cellular components.

• NecrosisRelated: Released lysosomal enzymes can help digest cells and tissue during necrosis.

• Golgi apparatusRelated: The Golgi supplies lysosomes with many of their digestive enzymes.

• Lysosomal storage diseaseNarrower topic: Storage diseases arise when this organelle cannot process or move its contents normally.

• PeroxisomeCompared with: Lysosomes digest macromolecules, whereas peroxisomes specialize in oxidation and detoxification.

• VacuoleCompared with: Lysosomes perform digestive functions that lytic vacuoles perform in plants.

• Ubiquitin–proteasome systemCompared with: Lysosomes provide a distinct degradation compartment for cargo outside the proteasome’s usual scope.

• Fabry diseaseNarrower topic: Fabry disease disrupts the lysosome’s normal breakdown of specific glycosphingolipids.

• Endomembrane systemBroader topic: It is a major endpoint for cargo sent for breakdown and recycling.

• Gaucher diseaseNarrower topic: Gaucher disease belongs to disorders caused by impaired lysosomal breakdown.

• Glycogen storage diseaseRelated: Pompe disease reflects impaired glycogen degradation within this compartment.

• Contractile vacuoleCompared with: Lysosomes digest cargo; contractile vacuoles chiefly regulate water balance.

• LumenRelated: Its lumen houses the acidic conditions and enzymes used for intracellular digestion.

• Christian de DuveBroader topic: De Duve identified this enzyme-rich compartment and named it the lysosome.

• Tay–Sachs diseaseBroader topic: Tay–Sachs results from failure of a lysosomal enzyme to break down its substrate.

• ChloroquineRelated: Chloroquine concentrates in acidic compartments and raises their pH, altering lysosomal functions.

• CystinosisBroader topic: Cystine builds up in this organelle when cystinosin is deficient.

• Krabbe diseaseNarrower topic: Galactocerebrosidase normally performs its lipid-degrading function inside this compartment.

• Metachromatic leukodystrophyNarrower topic: Defective lysosomal degradation lies at the start of the disease pathway.

• ProteasomeCompared with: Lysosomes handle bulk and membrane-associated cargo that is not directly fed into the proteasome.

• Albert ClaudeRelated: Claude’s methods helped create the experimental framework in which de Duve identified this organelle.

• EmperipolesisCompared with: Destruction by lysosomal digestion distinguishes many engulfment processes from emperipolesis.

• Farber diseaseNarrower topic: Acid ceramidase normally degrades ceramide within this cellular compartment.

• Glycogen storage disease type IINarrower topic: Pompe disease is specifically a failure of glycogen degradation inside this compartment.

• Hunter syndromeBroader topic: Iduronate-2-sulfatase normally acts here, so its deficiency disrupts lysosomal recycling.

• Morquio syndromeNarrower topic: The missing or deficient enzyme normally acts inside this cellular compartment.

• Sanfilippo syndromeRelated: The enzymes that fail in Sanfilippo syndrome normally work inside lysosomes.