KnowraMethotrexateLinked fromLinked fromThe 20 pages that link to Methotrexate, each with the reason it gives.All 20Broader topic 2Related 11Compared with 7Rheumatoid arthritisRelated: It is commonly the initial anchor medicine for controlling active rheumatoid arthritis.PsoriasisRelated: It is a systemic option for extensive skin disease or associated arthritis.Ectopic pregnancyRelated: It can stop growth of a small, unruptured ectopic pregnancy in selected patients.FolateRelated: It suppresses folate recycling, limiting nucleotide production in rapidly dividing cells.TrimethoprimCompared with: It targets the same enzyme but has different pharmacology and therapeutic uses.AntimetaboliteBroader topic: It blocks folate recycling, limiting nucleotide synthesis and rapidly dividing cell growth.Folic acidCompared with: It blocks folate recycling, the metabolic pathway that folic acid ultimately supports.AzathioprineCompared with: It is another antimetabolite used in autoimmune disease, but acts mainly through folate pathways.Megaloblastic anemiaRelated: Its interference with folate metabolism can impair DNA synthesis and cause megaloblastic changes.Psoriatic arthritisRelated: It is commonly used for peripheral joint and skin disease.PyrimidineRelated: It can reduce thymidylate synthesis indirectly by limiting folate-dependent one-carbon metabolism.CyclophosphamideCompared with: It suppresses cell growth through folate metabolism rather than DNA alkylation.Disease-modifying antirheumatic drugBroader topic: Methotrexate is the anchor conventional drug against which many treatment plans are built.One-carbon metabolismRelated: Its disruption of folate recycling limits nucleotide synthesis and cell proliferation.Dihydrofolate reductaseRelated: Its inhibition of the human enzyme limits folate-dependent nucleotide production.InfliximabRelated: It is commonly combined with infliximab for rheumatoid arthritis and can reduce anti-drug antibody formation.PyrimethamineCompared with: It shares the enzyme target but has different clinical uses and toxicity considerations.MercaptopurineCompared with: It is commonly paired with mercaptopurine in leukemia maintenance but blocks a different metabolic pathway.Relapsing polychondritisRelated: It may reduce relapses or help spare glucocorticoids in persistent disease.SulfasalazineCompared with: It is a common alternative disease-modifying treatment for rheumatoid arthritis, with a different mechanism and monitoring profile.
KnowraMethotrexateLinked fromLinked fromThe 20 pages that link to Methotrexate, each with the reason it gives.All 20Broader topic 2Related 11Compared with 7Rheumatoid arthritisRelated: It is commonly the initial anchor medicine for controlling active rheumatoid arthritis.PsoriasisRelated: It is a systemic option for extensive skin disease or associated arthritis.Ectopic pregnancyRelated: It can stop growth of a small, unruptured ectopic pregnancy in selected patients.FolateRelated: It suppresses folate recycling, limiting nucleotide production in rapidly dividing cells.TrimethoprimCompared with: It targets the same enzyme but has different pharmacology and therapeutic uses.AntimetaboliteBroader topic: It blocks folate recycling, limiting nucleotide synthesis and rapidly dividing cell growth.Folic acidCompared with: It blocks folate recycling, the metabolic pathway that folic acid ultimately supports.AzathioprineCompared with: It is another antimetabolite used in autoimmune disease, but acts mainly through folate pathways.Megaloblastic anemiaRelated: Its interference with folate metabolism can impair DNA synthesis and cause megaloblastic changes.Psoriatic arthritisRelated: It is commonly used for peripheral joint and skin disease.PyrimidineRelated: It can reduce thymidylate synthesis indirectly by limiting folate-dependent one-carbon metabolism.CyclophosphamideCompared with: It suppresses cell growth through folate metabolism rather than DNA alkylation.Disease-modifying antirheumatic drugBroader topic: Methotrexate is the anchor conventional drug against which many treatment plans are built.One-carbon metabolismRelated: Its disruption of folate recycling limits nucleotide synthesis and cell proliferation.Dihydrofolate reductaseRelated: Its inhibition of the human enzyme limits folate-dependent nucleotide production.InfliximabRelated: It is commonly combined with infliximab for rheumatoid arthritis and can reduce anti-drug antibody formation.PyrimethamineCompared with: It shares the enzyme target but has different clinical uses and toxicity considerations.MercaptopurineCompared with: It is commonly paired with mercaptopurine in leukemia maintenance but blocks a different metabolic pathway.Relapsing polychondritisRelated: It may reduce relapses or help spare glucocorticoids in persistent disease.SulfasalazineCompared with: It is a common alternative disease-modifying treatment for rheumatoid arthritis, with a different mechanism and monitoring profile.