KnowraMethotrexateLinked fromLinked fromThe 20 pages that link to Methotrexate, each with the reason it gives.All 20Broader topic 2Related 11Compared with 7Rheumatoid arthritisRelated: It is commonly the initial anchor medicine for controlling active rheumatoid arthritis.PsoriasisRelated: It is a systemic option for extensive skin disease or associated arthritis.Ectopic pregnancyRelated: It can stop growth of a small, unruptured ectopic pregnancy in selected patients.FolateRelated: It suppresses folate recycling, limiting nucleotide production in rapidly dividing cells.Megaloblastic anemiaRelated: Its interference with folate metabolism can impair DNA synthesis and cause megaloblastic changes.Psoriatic arthritisRelated: It is commonly used for peripheral joint and skin disease.PyrimidineRelated: It can reduce thymidylate synthesis indirectly by limiting folate-dependent one-carbon metabolism.One-carbon metabolismRelated: Its disruption of folate recycling limits nucleotide synthesis and cell proliferation.Dihydrofolate reductaseRelated: Its inhibition of the human enzyme limits folate-dependent nucleotide production.InfliximabRelated: It is commonly combined with infliximab for rheumatoid arthritis and can reduce anti-drug antibody formation.Relapsing polychondritisRelated: It may reduce relapses or help spare glucocorticoids in persistent disease.