Linked from

The 13 pages that link to P-glycoprotein, each with the reason it gives.

• Blood–brain barrierRelated: This efflux transporter returns many compounds from endothelial cells to the blood.

• BioavailabilityRelated: Its efflux activity can reduce the amount of an oral drug absorbed into blood.

• IvermectinRelated: P-glycoprotein helps keep ivermectin out of the mammalian brain; impaired transport can increase toxicity.

• PaclitaxelRelated: Its overexpression can pump paclitaxel out of tumor cells and weaken treatment.

• PiperineRelated: Piperine can inhibit this transporter, one proposed route for increasing absorption of some drugs.

• DigoxinRelated: Inhibiting this transporter can raise digoxin concentrations and increase adverse-effect risk.

• Second-generation antihistamineRelated: Its efflux activity helps keep some antihistamines out of the brain.

• ColchicineRelated: Inhibiting this transporter can raise colchicine exposure and increase toxicity risk.

• DoxorubicinRelated: Its activity can pump doxorubicin out of tumor cells and contribute to drug resistance.

• LoperamideRelated: At the blood–brain barrier, it limits loperamide entry into the brain at ordinary doses.

• ApixabanRelated: Its inhibition or induction can alter apixaban concentrations in the body.

• VincristineRelated: Its efflux of vincristine can contribute to resistance in cancer cells.

• BerberineRelated: Its transport activity can limit berberine absorption and affect concentrations of other compounds.