Linked from

The 14 pages that link to Protein misfolding, each with the reason it gives.

• ProteinRelated: Misfolding can impair protein function or cause harmful aggregates.

• Protein foldingCompared with: It is the failure mode against which successful folding is defined.

• Protein denaturationCompared with: Misfolding produces an abnormal structure, while denaturation describes disruption of the native structure.

• Protein structureCompared with: It shows how departures from a functional structure can damage cells or form aggregates.

• NeurodegenerationRelated: Misfolded proteins accumulate in several neurodegenerative diseases and can disrupt neuronal function.

• PrionNarrower topic: Prion propagation is a distinctive infectious form of protein misfolding.

• AmyloidRelated: Misfolded conformations can expose surfaces that promote amyloid assembly.

• Spinocerebellar ataxiaRelated: Abnormal protein handling is one proposed route from mutation to neuronal dysfunction.

• Alpha-1 antitrypsin deficiencyRelated: Misfolded alpha-1 antitrypsin can be retained inside liver cells.

• Stanley B. PrusinerRelated: Prusiner’s model explains prion propagation through templated changes in protein shape.

• Transmissible spongiform encephalopathyRelated: Misfolding gives prion proteins the ability to template further abnormal folding.

• Christian B. AnfinsenRelated: Real cells show that a sequence’s folding outcome depends on conditions and cellular assistance.

• Neurodegenerative diseaseRelated: Misfolded proteins accumulate in several disorders, though their roles differ by disease.

• Biomolecular & subcellular processesRelated: Misfolded proteins can overwhelm quality-control systems and damage cells.