Linked from

The 17 pages that link to Purine metabolism, each with the reason it gives.

• GoutNarrower topic: Purine breakdown produces urate, the material that forms gout-causing crystals.

• GlycineRelated: Glycine contributes atoms directly to the purine ring during nucleotide synthesis.

• Uric acidNarrower topic: Uric acid is the final product of purine breakdown in humans.

• AllopurinolNarrower topic: Allopurinol acts on the final stages of purine breakdown.

• GuanineNarrower topic: Guanine is both a product of purine synthesis and a substrate in its breakdown.

• HyperuricemiaNarrower topic: Excess urate can result when purine breakdown outpaces removal.

• Tumor lysis syndromeRelated: Purine breakdown generates uric acid after tumor cells release nucleic acids.

• AzathioprineNarrower topic: Azathioprine’s active metabolites interfere with this broader system of nucleotide production and use.

• Xanthine oxidaseNarrower topic: Xanthine oxidase catalyzes terminal reactions in the degradation branch.

• Adenosine monophosphateRelated: AMP is both a product and a substrate in purine metabolism.

• FebuxostatNarrower topic: Uric acid production is the endpoint of purine breakdown that febuxostat suppresses.

• Guanosine triphosphateNarrower topic: GTP production and degradation are part of the broader metabolism of guanine and adenine nucleotides.

• Mycophenolate mofetilNarrower topic: The drug disrupts one route within this broader network.

• Lesch–Nyhan syndromeRelated: Biochemical investigation of this pathway revealed the syndrome’s metabolic defect.

• InosineNarrower topic: Inosine is an intermediate in purine breakdown and salvage.

• Gertrude B. ElionRelated: Blocking purine pathways provided a way to limit leukemia-cell growth.

• MercaptopurineNarrower topic: Mercaptopurine interferes with this network by disrupting nucleotide production and use.