KnowraPyruvate dehydrogenase complexLinked fromLinked fromThe 8 pages that link to Pyruvate dehydrogenase complex, each with the reason it gives.All 8Related 5Compared with 3Acetyl-CoARelated: It makes acetyl-CoA from glucose-derived pyruvate.Lactate dehydrogenaseCompared with: Unlike lactate dehydrogenase, it irreversibly channels pyruvate toward mitochondrial oxidation.DecarboxylationRelated: Its E1 subunit catalyzes a cofactor-dependent decarboxylation of pyruvate.ThiamineRelated: Its first catalytic step requires thiamine pyrophosphate to process carbohydrate-derived pyruvate.Pyruvate carboxylaseCompared with: It irreversibly oxidizes pyruvate, whereas pyruvate carboxylase adds carbon to it.Leigh syndromeRelated: Defects can impair energy metabolism and produce a Leigh syndrome presentation.Oxaloacetic acidCompared with: This competing fate of pyruvate does not directly replenish oxaloacetate.Pyruvic acidRelated: This reaction commits pyruvate to aerobic oxidation and links glycolysis to the citric acid cycle.