KnowraTrimethoprimLinked fromLinked fromThe 12 pages that link to Trimethoprim, each with the reason it gives.All 12Broader topic 2Related 5Compared with 5HyperkalemiaRelated: Its potassium-retaining effect can contribute to hyperkalemia, particularly with kidney disease or interacting drugs.SulfonamideRelated: It blocks a later step in folate metabolism and is often paired with sulfamethoxazole.AntimetaboliteBroader topic: It selectively disrupts bacterial folate metabolism, illustrating antimicrobial use of antimetabolites.Bacteriostatic agentBroader topic: Alone, trimethoprim is typically bacteriostatic; combination with sulfamethoxazole can alter the effect.CreatinineRelated: It may raise serum creatinine without a corresponding fall in filtration.Dihydrofolate reductaseRelated: Its preference for bacterial enzyme variants enables selective antimicrobial action.DapsoneCompared with: It blocks a different enzyme and is often paired with sulfamethoxazole rather than dapsone.NitrofurantoinCompared with: It is an alternative for uncomplicated cystitis when local resistance and patient factors permit.PyrimethamineCompared with: It targets the same enzyme class but is used mainly against bacteria.FosfomycinCompared with: It is another possible urinary antibiotic, but its usefulness depends on local susceptibility.Gertrude B. ElionRelated: Its selective folate-pathway inhibition reflects the drug-design strategy Elion and Hitchings advanced.HexamethylenetetramineCompared with: It prevents urinary infections through a targeted enzyme blockade, unlike methenamine's local formaldehyde release.