KnowraTrimethoprimLinked fromLinked fromThe 12 pages that link to Trimethoprim, each with the reason it gives.All 12Broader topic 2Related 5Compared with 5HyperkalemiaRelated: Its potassium-retaining effect can contribute to hyperkalemia, particularly with kidney disease or interacting drugs.SulfonamideRelated: It blocks a later step in folate metabolism and is often paired with sulfamethoxazole.CreatinineRelated: It may raise serum creatinine without a corresponding fall in filtration.Dihydrofolate reductaseRelated: Its preference for bacterial enzyme variants enables selective antimicrobial action.Gertrude B. ElionRelated: Its selective folate-pathway inhibition reflects the drug-design strategy Elion and Hitchings advanced.