Linked from

The 21 pages that link to Cisplatin, each with the reason it gives.

• Coordination complexBroader topic: This coordination complex damages cancer-cell DNA after ligand substitution.

• Cis–trans isomerismRelated: Its cis coordination geometry is essential to its anticancer activity.

• LigandBroader topic: Its chloride ligands are replaced in aqueous environments, enabling platinum to bind DNA.

• Coordination chemistryBroader topic: Its square-planar platinum center binds cellular targets after ligand substitution.

• IsomerRelated: Its trans arrangement is a distinct isomer with different biological effects.

• IsomerismRelated: Its square-planar geometry distinguishes the active cis complex from the trans isomer.

• NephrotoxicityBroader topic: Its tubular toxicity is a major limit on treatment dosing.

• Geometric isomerismRelated: Its cis geometry enables DNA cross-linking that its trans counterpart does not achieve effectively.

• PaclitaxelCompared with: It kills cancer cells through DNA damage rather than microtubule stabilization.

• OtotoxicityBroader topic: Cisplatin can cause lasting, often high-frequency hearing loss.

• Nucleotide excision repairRelated: Nucleotide excision repair removes some cisplatin-induced DNA adducts, influencing drug response.

• Chemotherapy-induced peripheral neuropathyBroader topic: Cisplatin neuropathy often emerges with cumulative exposure and may persist after treatment.

• Square planar molecular geometryBroader topic: Its geometry fixes the relative positions of the ligands involved in DNA binding.

• MesotheliomaRelated: Cisplatin has been used in combination regimens for unresectable pleural mesothelioma.

• Testicular cancerBroader topic: It is the key drug behind the high curability of metastatic testicular cancer.

• CarboplatinCompared with: It shares carboplatin’s core DNA-damaging action but generally causes more kidney and nerve toxicity.

• Group 10 elementBroader topic: This platinum compound shows how a group 10 metal can become a medicine.

• Inorganic compoundBroader topic: It demonstrates how an inorganic metal complex can act as a medicine.

• Coordination sphereBroader topic: Its ligand sphere governs aquation and DNA binding in cancer treatment.

• History of cancerBroader topic: Its success in testicular cancer helped demonstrate that chemotherapy could cure some advanced cancers.

• Inorganic chemicalsBroader topic: It demonstrates how an inorganic complex can act as a medicine.