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The 48 pages that link to Complement system, each with the reason it gives.

• InflammationRelated: Complement fragments attract immune cells and amplify inflammatory signaling.

• AntibodyRelated: Antibodies can activate this cascade after binding a target.

• PhagocytosisRelated: Complement fragments can coat microbes and promote their phagocytic uptake.

• Immune systemRelated: Its protein cascade recruits defenses, tags microbes, and can rupture them.

• Blood plasmaRelated: Complement proteins circulate in plasma and become active during immune responses.

• NeutrophilRelated: Complement fragments attract neutrophils and coat microbes for easier engulfment.

• NeuroinflammationRelated: Complement signaling can shape synapse removal and inflammatory injury in the brain.

• Guillain–Barré syndromeRelated: Antibody-triggered complement activity contributes to nerve injury in some forms of the syndrome.

• Innate immune systemRelated: Complement supplies soluble defenses that act rapidly alongside immune cells.

• Age-related macular degenerationRelated: Complement activity is implicated in retinal inflammation and the development of atrophic disease.

• HemolysisRelated: Complement pores can rupture red cells during immune-mediated hemolysis.

• Systemic lupus erythematosusRelated: Low complement levels can reflect consumption during active immune-complex disease in SLE.

• AngioedemaRelated: Complement abnormalities can increase bradykinin production in hereditary angioedema.

• Autoimmune diseaseRelated: Complement activation can amplify antibody-mediated inflammation and tissue injury.

• ImmunologyRelated: Complement links innate recognition to pathogen clearance and antibody activity.

• Adaptive immune systemRelated: Complement is an innate defense that antibodies can also recruit.

• ImmunodeficiencyBroader topic: Complement deficiencies compromise specific antimicrobial functions despite otherwise intact immune cells.

• XenotransplantationRelated: Human complement can attack graft tissue unless its activity is controlled.

• C-reactive proteinRelated: CRP bound to a target can recruit complement through the classical pathway.

• Ischemia-reperfusion injuryRelated: Complement activation can amplify inflammation when circulation exposes injured tissue to plasma proteins.

• LectinRelated: Mannose-binding lectin can activate this immune defense network.

• AutoantibodyRelated: Some autoantibodies activate complement, amplifying damage to their target tissues.

• Intravenous immunoglobulinRelated: Pooled antibodies can bind complement components and limit tissue injury in some disorders.

• IgA nephropathyRelated: Complement activation in glomeruli helps sustain injury, often through lectin and alternative pathways.

• Hemolytic uremic syndromeRelated: Uncontrolled complement activity causes many cases of atypical hemolytic uremic syndrome.

• Bacterial capsuleRelated: Some capsules reduce complement deposition or protect cells from its effects.

• Neisseria meningitidisRelated: Complement-mediated killing is a key defense against meningococci in blood.

• Antiphospholipid syndromeRelated: Complement activation contributes to tissue injury in some antiphospholipid-related pregnancy complications.

• Autoimmune hemolytic anemiaRelated: Complement can tag or directly lyse red cells targeted by antibodies.

• GlomerulonephritisRelated: Complement activation contributes to injury and provides useful clues about disease cause.

• InterferonCompared with: Complement provides a protein-based defense that does not depend on interferon receptor signaling.

• Capsular polysaccharideRelated: Capsules can interfere with complement deposition, reducing one route to bacterial clearance.

• Post-streptococcal glomerulonephritisRelated: Complement activation, especially of C3, is associated with the glomerular injury.

• Neisseria gonorrhoeaeRelated: Resistance to complement-mediated killing helps gonococci survive in human tissues and fluids.

• Paroxysmal nocturnal hemoglobinuriaNarrower topic: Its terminal pathway causes the intravascular hemolysis characteristic of PNH.

• Primary immunodeficiencyBroader topic: Inherited complement defects create recognizable gaps in antimicrobial defense.

• White blood cellRelated: Complement cooperates with leukocytes by tagging targets and amplifying recruitment.

• Neuromyelitis optica spectrum disorderRelated: Complement activation is a major mechanism by which aquaporin-4 antibodies injure astrocytes.

• Goodpasture syndromeRelated: Complement activation contributes to inflammatory tissue damage after antibodies bind basement membranes.

• Jules BordetBroader topic: Bordet identified this heat-sensitive system as a partner to antibodies in bacterial destruction.

• DermatomyositisRelated: Complement deposition in small vessels is implicated in dermatomyositis tissue injury.

• NeisseriaRelated: Resistance to complement-mediated killing is a key Neisseria survival mechanism.

• Bloodstream infectionRelated: Complement circulates in plasma and can mark or directly damage pathogens in the bloodstream.

• Membranoproliferative glomerulonephritisRelated: Its overactivation drives complement-mediated forms of the disease.

• Biochemical cascadeBroader topic: Complement proteins activate successive components to amplify recognition of pathogens.

• BorreliaRelated: Some Borrelia surface proteins interfere with complement, supporting survival in vertebrate hosts.

• Hemic and Immune SystemsRelated: Its circulating proteins help mark microbes, recruit cells, and damage targets.

• Immune system phenomenaRelated: It shows how soluble proteins can amplify immune defense.