Linked from

The 40 pages that link to Cystic fibrosis, each with the reason it gives.

• BiofilmRelated: Biofilm-forming bacteria contribute to persistent airway infections in many affected people.

• Protein foldingBroader topic: The common CFTR variant ΔF508 causes defective folding and trafficking of the protein.

• Ion channelRelated: CFTR is an ATP-regulated chloride channel whose dysfunction disrupts salt and water transport.

• ChlorideRelated: Defective chloride transport contributes to thick mucus in the disease.

• Endoplasmic reticulumRelated: Some CFTR variants are retained and degraded after failing ER folding quality control.

• GlutathioneRelated: Altered glutathione levels in airway secretions have been studied in cystic fibrosis.

• Preimplantation genetic testingRelated: Embryos can be tested when both genetic parents carry relevant CFTR variants.

• Mucociliary clearanceRelated: Abnormal airway surface hydration contributes to thick secretions and impaired clearance.

• CiliaCompared with: It disrupts mucociliary clearance mainly by altering airway surface hydration and mucus, not ciliary structure.

• MucusRelated: Dehydrated, thick airway mucus contributes to obstruction and chronic infection.

• PancreasRelated: Blocked pancreatic ducts can prevent digestive enzymes from reaching the intestine.

• Genotype–phenotype correlationBroader topic: CFTR variant classes correlate with some disease features but do not fully predict severity.

• BicarbonateRelated: Impaired bicarbonate secretion contributes to unusually thick secretions in affected tissues.

• Pseudomonas aeruginosaRelated: Chronic P. aeruginosa airway infection is a major complication for many people with cystic fibrosis.

• Eccrine sweat glandRelated: Abnormally salty sweat reflects altered ion handling in sweat ducts.

• Protein misfoldingBroader topic: The common F508del variant causes CFTR misfolding and its premature degradation.

• N-acetylcysteineRelated: Mucus thinning motivated investigation of N-acetylcysteine, though clinical benefit is not established.

• SweatingRelated: Abnormally salty sweat is a basis for a standard diagnostic test.

• AlginateRelated: Alginate-producing Pseudomonas biofilms are associated with chronic lung infections in many affected people.

• Epithelial cellsRelated: Defective epithelial ion transport thickens secretions in the lungs and other organs.

• MalabsorptionRelated: Thick secretions can obstruct pancreatic ducts and lead to enzyme-related malabsorption.

• Vitamin A deficiencyBroader topic: Pancreatic insufficiency in cystic fibrosis can impair fat-soluble vitamin absorption.

• Exocrine glandRelated: Altered duct secretions can obstruct exocrine tissues, especially in the lungs and pancreas.

• Facilitated diffusionBroader topic: Defective CFTR channel function disrupts epithelial salt and water movement.

• Nasal polypsRelated: It can cause chronic sinus disease and nasal polyps, particularly in children.

• BronchiectasisCompared with: It is a distinct underlying disease that can lead to bronchiectasis.

• Alpha-1 antitrypsin deficiencyCompared with: It can cause lung disease through a different gene and mechanism.

• AztreonamRelated: Inhaled aztreonam is used to suppress Pseudomonas aeruginosa in some people with this disease.

• CeftazidimeRelated: Ceftazidime may treat susceptible Pseudomonas lung infections in people with this condition.

• PilocarpineRelated: Pilocarpine-induced sweat collection supports diagnostic testing for this disease.

• Sweat glandRelated: Abnormally salty sweat provides a basis for a standard diagnostic test.

• TobramycinRelated: Inhaled tobramycin suppresses chronic Pseudomonas aeruginosa infection in many people with this disease.

• AcetylcysteineRelated: Its tenacious airway mucus illustrates the clinical problem mucolytics aim to ease.

• Recessive traitBroader topic: It is a well-known example of an autosomal recessive condition.

• Respiratory mucosaCompared with: Impaired airway hydration disrupts mucus clearance and exposes the system's dependence on fluid balance.

• Bodily secretionsRelated: It demonstrates how altered salt and water movement changes mucus and other secretions.

• Congenital, Hereditary, and Neonatal Diseases and AbnormalitiesBroader topic: It exemplifies an inherited disease included in the category.

• Fluids and SecretionsRelated: Altered salt and water transport thickens mucus and disrupts airway and digestive function.

• Günter BlobelRelated: Misfolded CFTR can be retained and degraded rather than reaching the cell surface.

• Transport (biology)Related: Impaired epithelial ion transport disrupts water movement and thickens mucus.