Linked from

The 36 pages that link to Leaving group, each with the reason it gives.

• HydrolysisRelated: Its departure often enables water to replace it during hydrolysis.

• Nucleophilic substitutionNarrower topic: Its ability to depart strongly affects substitution rate and feasibility.

• Functional groupRelated: Its stability often determines whether substitution or elimination at a functional group can proceed.

• CarbocationRelated: Departure of a leaving group commonly generates a carbocation.

• NucleophileRelated: In substitution, nucleophilic bond formation is coupled to departure of this group.

• Nucleophilic acyl substitutionRelated: Its ability to depart determines whether the tetrahedral intermediate collapses.

• Conjugate baseCompared with: A stable leaving group is often a weak base, but it need not be discussed as an acid's conjugate base.

• Dehydration reactionNarrower topic: Water must depart from the substrate for dehydration to proceed.

• Nucleophilic aromatic substitutionRelated: Its departure restores aromaticity after nucleophilic addition in the stepwise pathway.

• Elimination reactionNarrower topic: Elimination requires a group to leave as a new bond forms.

• SN2 reactionRelated: Its ability to depart helps determine whether the concerted substitution is favorable.

• Carbocation rearrangementRelated: Leaving-group departure commonly generates the carbocation that can rearrange.

• AlkylationRelated: A good leaving group makes many alkyl-transfer reactions proceed more readily.

• E2 reactionRelated: Its departure is synchronized with proton removal and alkene formation.

• SN1 reactionRelated: Its departure in the slow ionization step determines whether the carbocation can form readily.

• Ester hydrolysisRelated: Proton transfer makes the ester’s alkoxy group more capable of leaving during acid-catalyzed cleavage.

• Condensation reactionRelated: The departing small molecule or its components must be expelled as the new bond forms.

• E1 reactionRelated: Its departure creates the carbocation in the first E1 step.

• Fischer esterificationRelated: Water leaves the tetrahedral intermediate as the ester-forming step proceeds.

• Hofmann eliminationNarrower topic: The attached tertiary amine departs as the quaternary ammonium bond breaks.

• Williamson ether synthesisRelated: The organic halide’s leaving group departs as the new carbon–oxygen bond forms.

• Acyl chlorideNarrower topic: Chloride’s departure enables substitution at the acyl carbon.

• Acyl groupRelated: Acyl substitution requires displacement of the group bonded to the acyl carbon.

• N-alkylationRelated: Leaving-group ability strongly affects substitution-based N-alkylation.

• Organic reactionRelated: Leaving-group ability often determines whether substitution or elimination can occur.

• Acetyl chlorideRelated: Chloride leaves from the acyl carbon during nucleophilic acyl substitution.

• HaloalkaneNarrower topic: The halide’s ability to leave helps determine the rate of substitution and elimination.

• SNi reactionRelated: Its departure initiates the ion-pair stage of the mechanism.

• Allylic rearrangementRelated: Its departure initiates substitution or ionization in common rearrangement pathways.

• Arrow pushingRelated: An arrow from the bond to this group depicts heterolytic bond cleavage.

• Electrophilic substitutionRelated: In the common aromatic case, hydrogen leaves after electrophile attachment.

• Sodium ethoxideRelated: Ethoxide’s competing substitution and elimination pathways depend on the substrate’s leaving group.

• 1,2-RearrangementRelated: Its departure can create the conditions that trigger a neighboring shift.

• E1cB elimination reactionRelated: Its departure follows carbanion formation in the defining stepwise pathway.

• Ei mechanismRelated: Its departure is one of the coordinated events in Ei elimination.

• IodomethaneRelated: Iodide leaves readily, helping make iodomethane highly reactive toward nucleophiles.