Linked from

The 25 pages that link to Sickle cell disease, each with the reason it gives.

• HemoglobinBroader topic: A single amino-acid substitution in beta globin creates hemoglobin S, which polymerizes when deoxygenated.

• ProteinBroader topic: A single amino-acid substitution in hemoglobin illustrates how sequence changes can affect health.

• PhenotypeBroader topic: Its clinical phenotype varies with genotype, environment, and medical care.

• Hematopoietic stem cell transplantationRelated: Donor stem cells can establish production of red cells without sickle hemoglobin.

• CRISPR gene editingRelated: CRISPR-based treatment can alter blood stem cells to reduce disease symptoms.

• Red blood cellBroader topic: It shows how a hemoglobin mutation can alter cell shape, survival, and blood flow.

• Linus PaulingRelated: Pauling’s work identified it as a molecular disease caused by altered hemoglobin.

• Genotype–phenotype correlationBroader topic: Different genotypes and modifying factors contribute to varied clinical severity.

• HemolysisBroader topic: Sickling and membrane damage contribute to chronic hemolysis.

• Hemolytic anemiaBroader topic: Sickling shortens red-cell survival and causes chronic hemolytic anemia.

• Peripheral blood smearRelated: Sickled cells can be directly recognized on a stained film.

• SpleenRelated: Repeated splenic injury can lead to loss of splenic function in affected people.

• J. B. S. HaldaneRelated: Haldane proposed that malaria could maintain harmful blood disorders through heterozygote advantage.

• Bone-marrow transplantationRelated: Transplantation can replace the blood-forming system that produces sickled cells.

• Genome editingBroader topic: Edited blood stem cells provide a prominent clinical application of genome editing.

• Base editingRelated: Base editing strategies can alter hemoglobin-related DNA to raise fetal hemoglobin or address disease-causing variants.

• Glucose-6-phosphate dehydrogenase deficiencyCompared with: Both are inherited red-cell disorders, but their molecular defects and triggers differ.

• Avascular necrosisRelated: Sickled cells can obstruct small vessels and cause bone ischemia.

• Medical racismRelated: Its care has been shaped by racial stigma and persistent undertreatment of pain.

• PriapismRelated: Sickling can obstruct penile blood flow and trigger recurrent or prolonged erections.

• Point mutationBroader topic: A single-base substitution in HBB causes the classic sickle hemoglobin change.

• Recessive traitBroader topic: The disease phenotype generally requires pathogenic HBB variants on both gene copies.

• HydroxycarbamideRelated: Hydroxycarbamide reduces painful crises and other complications for many people with this disorder.

• Lethal alleleCompared with: The severe disease genotype is harmful but is not universally lethal, distinguishing it from a lethal genotype.

• Victor A. McKusickRelated: It exemplifies how inherited variation can be connected to a distinctive clinical disorder.