KnowraSickle cell diseaseLinked fromLinked fromThe 25 pages that link to Sickle cell disease, each with the reason it gives.All 25Broader topic 10Related 13Compared with 2HemoglobinBroader topic: A single amino-acid substitution in beta globin creates hemoglobin S, which polymerizes when deoxygenated.ProteinBroader topic: A single amino-acid substitution in hemoglobin illustrates how sequence changes can affect health.PhenotypeBroader topic: Its clinical phenotype varies with genotype, environment, and medical care.Red blood cellBroader topic: It shows how a hemoglobin mutation can alter cell shape, survival, and blood flow.Genotype–phenotype correlationBroader topic: Different genotypes and modifying factors contribute to varied clinical severity.HemolysisBroader topic: Sickling and membrane damage contribute to chronic hemolysis.Hemolytic anemiaBroader topic: Sickling shortens red-cell survival and causes chronic hemolytic anemia.Genome editingBroader topic: Edited blood stem cells provide a prominent clinical application of genome editing.Point mutationBroader topic: A single-base substitution in HBB causes the classic sickle hemoglobin change.Recessive traitBroader topic: The disease phenotype generally requires pathogenic HBB variants on both gene copies.