Linked from

The 25 pages that link to Sickle cell disease, each with the reason it gives.

• Hematopoietic stem cell transplantationRelated: Donor stem cells can establish production of red cells without sickle hemoglobin.

• CRISPR gene editingRelated: CRISPR-based treatment can alter blood stem cells to reduce disease symptoms.

• Linus PaulingRelated: Pauling’s work identified it as a molecular disease caused by altered hemoglobin.

• Peripheral blood smearRelated: Sickled cells can be directly recognized on a stained film.

• SpleenRelated: Repeated splenic injury can lead to loss of splenic function in affected people.

• J. B. S. HaldaneRelated: Haldane proposed that malaria could maintain harmful blood disorders through heterozygote advantage.

• Bone-marrow transplantationRelated: Transplantation can replace the blood-forming system that produces sickled cells.

• Base editingRelated: Base editing strategies can alter hemoglobin-related DNA to raise fetal hemoglobin or address disease-causing variants.

• Avascular necrosisRelated: Sickled cells can obstruct small vessels and cause bone ischemia.

• Medical racismRelated: Its care has been shaped by racial stigma and persistent undertreatment of pain.

• PriapismRelated: Sickling can obstruct penile blood flow and trigger recurrent or prolonged erections.

• HydroxycarbamideRelated: Hydroxycarbamide reduces painful crises and other complications for many people with this disorder.

• Victor A. McKusickRelated: It exemplifies how inherited variation can be connected to a distinctive clinical disorder.