Linked from

The 37 pages that link to Voltage-gated sodium channel, each with the reason it gives.

• Action potentialRelated: Sodium influx drives the rising phase of many neuronal action potentials.

• Local anestheticRelated: Local anesthetics bind these channels and reduce the sodium current needed to propagate nerve impulses.

• AlkaloidRelated: Some alkaloids block these channels, disrupting nerve and muscle activity.

• AxonRelated: Its opening helps initiate and propagate action potentials in axonal membranes.

• NociceptorRelated: These channels carry nociceptor action potentials toward the spinal cord.

• AnalgesicRelated: Local anesthetics block these channels, stopping nerve impulses that carry pain.

• InsecticideRelated: Pyrethroids disrupt these channels, causing persistent nerve firing and paralysis in insects.

• Cardiac action potentialRelated: Fast sodium entry initiates the steep upstroke in working atrial and ventricular cells.

• Local anesthesiaRelated: Local anesthetics bind these channels and prevent the electrical impulses that carry pain signals.

• NeurotoxinRelated: Tetrodotoxin and saxitoxin disrupt nerve impulses by blocking these channels.

• Antiseizure medicationRelated: Several antiseizure medicines limit repetitive neuronal firing by altering these channels.

• LidocaineBroader topic: Lidocaine binds these channels and reduces sodium entry, limiting electrical signaling.

• ValproateRelated: Valproate reduces repetitive neuronal firing partly by limiting sodium-channel activity.

• CarbamazepineRelated: Carbamazepine blocks these channels, limiting repeated electrical discharges in neurons.

• TetrodotoxinRelated: Tetrodotoxin binds to these channels and obstructs sodium entry.

• LamotrigineRelated: Lamotrigine inhibits sodium-channel activity, reducing repetitive neuronal firing.

• Saltatory conductionRelated: Dense sodium channels at nodes regenerate the action potential.

• PyrethroidRelated: Pyrethroids bind these channels and delay their closing, disrupting nerve impulses.

• Facilitated diffusionBroader topic: Its opening permits rapid passive sodium entry during action potentials.

• Local anesthetic systemic toxicityRelated: Local anesthetics block these channels in nerves and cardiac tissue when systemic concentrations rise.

• FuguBroader topic: Tetrodotoxin causes paralysis by blocking these channels in nerve and muscle cells.

• LevetiracetamCompared with: Several other antiseizure drugs target these channels, unlike levetiracetam's primary known target.

• Ciguatera fish poisoningBroader topic: Ciguatoxins keep these channels abnormally active, altering nerve and muscle signaling.

• Topical anestheticRelated: Most topical anesthetics reduce sensation by blocking these channels in sensory nerves.

• BenzocaineRelated: Benzocaine blocks these channels, preventing nerves from initiating and conducting pain signals.

• PermethrinRelated: Permethrin prolongs channel opening in arthropods, disrupting nerve signaling and causing paralysis.

• AnticonvulsantRelated: Several anticonvulsants reduce repetitive firing by limiting sodium-channel activity.

• BatrachotoxinRelated: Batrachotoxin binds these channels and prevents their normal inactivation.

• BupivacaineRelated: Bupivacaine binds these channels and suppresses the action potentials that carry pain signals.

• ProcaineRelated: Procaine reduces nerve impulses by inhibiting these channels from the inside.

• Rough-skinned newtBroader topic: Tetrodotoxin disables these channels, while resistant snakes carry channel variants that reduce toxin binding.

• TopiramateRelated: Topiramate reduces repetitive neuronal firing partly by limiting sodium-channel activity.

• AnestheticRelated: Local anesthetics block these channels to stop nerve impulses.

• Arizona bark scorpionBroader topic: Key venom toxins alter these channels, causing repetitive nerve and muscle activity.

• PhenytoinNarrower topic: Phenytoin binds preferentially to inactivated channels, reducing repeated electrical firing.

• Refractory period (neurophysiology)Related: Its transition into an inactivated state creates the absolute limit on firing.

• Tityus serrulatusRelated: Tityus serrulatus toxins alter these channels, disturbing electrical signaling in nerves.