Linked from

The 49 pages that link to Cancer, each with the reason it gives.

• ApoptosisRelated: Cancer cells can evade apoptotic signals, while many treatments aim to restore cell death.

• Gene expressionRelated: Disrupted expression of growth, survival, and identity genes contributes to tumor development.

• Cell cycleRelated: Cancer commonly involves mutations that weaken restraints on cell-cycle progression.

• MitosisRelated: Disrupted controls over mitotic entry and division contribute to tumor growth.

• Cell theoryRelated: Cancer shows how changes in individual cells can disrupt an organism’s larger organization.

• AutophagyRelated: Autophagy can suppress tumor initiation yet support established tumors under stress.

• Somatic mutationRelated: In animals, accumulated somatic mutations can contribute to cancer development.

• AneuploidyRelated: Aneuploidy is common in many cancers, but its role in tumor development varies.

• Gene regulatory networkRelated: Disrupted regulatory networks can alter growth, survival, and cell identity.

• CellRelated: Cancer arises when cellular growth and division escape normal regulation.

• DNA damage responseRelated: Accumulated mutations from failed damage control can drive cancer development.

• Cell polarityRelated: Disrupted epithelial polarity can accompany tumor progression and loss of tissue organization.

• CytokinesisRelated: Cytokinesis errors can contribute to chromosome instability in some cancers.

• Group selectionRelated: Multicellular organisms face conflict between selection among cells and cooperation at organism level.

• Theodor BoveriRelated: Boveri’s 1914 theory proposed that abnormal chromosome combinations could initiate cancer.

• Cell divisionRelated: Cancer can arise when controls on cell division fail.

• Cell-cycle checkpointRelated: Checkpoint defects can enable damaged cells to keep dividing.

• Programmed cell deathRelated: Cancer can arise when cells evade death signals, and many therapies aim to restore their sensitivity.

• CentrosomeRelated: Centrosome abnormalities are common in tumors and can contribute to chromosome instability.

• Guanosine triphosphateRelated: Mutations that impair GTP hydrolysis can keep Ras signaling active and promote cancer.

• TelomeraseRelated: Many cancers activate telomerase to maintain telomeres during continued cell division.

• Elizabeth BlackburnRelated: Many cancers reactivate telomerase, enabling continued cell division.

• Somatic cellRelated: Many cancers originate when somatic cells acquire changes that disrupt growth regulation.

• Paul NurseRelated: Disrupted cell-cycle regulation is a common feature of cancer.

• Leland H. HartwellRelated: Hartwell’s cell-cycle research helped clarify how disrupted division control can contribute to cancer.

• NucleolusRelated: Many cancers alter ribosome production and show changes in nucleolar size or activity.

• Raymond DamadianRelated: His early experiments compared magnetic resonance signals from cancerous and normal tissue.

• Jack W. SzostakRelated: Many cancers activate telomerase, linking chromosome-end maintenance to sustained cell division.

• Tim HuntRelated: Disrupted cyclin and cell-cycle control is a common feature of cancer.

• Regulation of gene expressionRelated: Cancer can arise when oncogenes are overexpressed or tumor-suppressor genes are silenced.